Final Destination 22 takes place Final Destination 21, Elisa remember her childhood best friend who got killed in train explosion and everbody who she know was killed by death (that before the Final Destination film series). She was get her own premonition from her mother's ex-boyfriend like Sam and Katie Lawton but they get own premonition from their father.
- Caitlin Carmichael as Elisa Brooks
- Danielle Panabaker as Adult Elisa Brooks
- Addy Miller as Casey Simpson/Elisa's childhood best friend
- Alina Foley as Sophie Brooks
- Vera Farmiga as Cassidy Brooks/Elisa and Sophie's mother
- Donnie Wahlberg as Luke Prescott/Cassidy's ex-boyfriend