NZT (thallanylzirconio-methyl-tetrahydro-triazatriphenylene) is a psychotropic medication that radically increases the brain's ability to absorb and process information – including those related to the senses. It works, in part, by maintaining higher levels of 5-HT in the synapse while increasing norepinephrine and serotonin neurotransmission by blocking presynaptic alpha-2 adrenergic receptors while at the same time blocking certain serotonin receptors.

It is a nitrogen-based psychotropic that impacts specific brain activity in several ways but most significantly by elevating receptivity and synaptic sharing between the hippocampus, the amygdala and the striatum. In controlled doses, taken over the course of a relatively short period of time, NZT significantly improves both short-term and long-term memory, memory capacity, and the analytical purposing of memory. Because it also impacts the sympathetic and parasympathetic nervous systems, NZT can improve higher brain function, hand-eye coordination, muscle memory and even the body's immune system. In some people, NZT can even induce lucid dreaming and what is sometimes called 'fugue state'.

When taken as under a regimen of one pill per day for seven consecutive days, NZT is 97.3% effective in improving memory, hand-eye coordination and a host of cognitive abilities.

Typically, a person will experience feelings of euphoria within 30 to 60 seconds of taking NZT. They will then experience significantly increased memory – both in capacity and speed of recall – within the first 24 hours of taking their first dose of NZT. They will be able to digest vast amounts of information in a very short amount of time – a foreign language, for instance; they will be able to memorize not only a considerable amount of vocabulary but usage rules, idiomatics, phrases, sentences and situational expressions.

Because NZT is a brain stimulant, it will reduce the brain's need for extended rest periods; i.e. sleep. Also, NZT may allow a person to exercise for longer periods with greater efficacy. They will feel stronger, faster, more focused.

Most people who continue taking NZT beyond an initial seven-day regimen will experience other psychological and sensory enhancements including improved hearing, vision, taste and smell.


  • The medication is seen in the 2011 film Limitless.
  • It is also seen in the TV series Limitless.

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