Scream: Ghostface Radio takes place after The Truth Of Lauren Malloy, Sidney becomes a the host of a show called Ghostface Radio in which she talks about her experiences with the past Ghostface killers, One night she gets a phonecall from a new killer who tells her it's starting again, soon after afterwards fans of the show are being killed. The killer also a personal vendetta against Kirby. Do not deleat this or I'll smack your face.
- Gary Sinise as Detective Frank Nightingale
- Alicia Silverstone as Detective Emma Lloyd
- Neve Campbell as Sidney Prescott
- Georgie Henley as Hayley McDonald
- Hayden Pantierre as Kirby Reed
- Emma Bell as Cami Watson
- Josh Brolin as Robert Morgan
- Michael Madsen as Det Dennis Mitchell
- Lisa Wilcox as Det. Natalie Carmen
- Molly Burnette as Caroline Mitchell
- Ellen Wroe as Brianna Albertson
- Dakota Fanning as Missy Gibson
- Michael Emerson as Jack Murphy
- Matthew Knight as Roy Popper
- Jimmy Bennet as Louis
- Julie Benz as Beverly Reed
- Elizabeth Gillies as Carrie Stout
- Ariana Grande as Niley Krinkey
- Sarah Hyland as Tess Martin
- Ryan Kwanten as Officer Pecard
- Heather Matazarro as Martha Meeks
- Callan McAuliffe as Joseph Morris
- Ian Samerhalder as Mr. Leeds
- Amanda Brynes as Mariah
- Jason Earles as Mitchell
- Seth Rogan as Carl
- Justin Chatwin as Harold
- Caitlyn Taylor Love as Shirley
- Logan Lerman as Richie
Jamie Kenndey as Randy Meeks-He is in a videotape that Martha and Sidney are watching he is talking about more rules in horror movies.
Selena Gomez as Jackie Lever-She is shown in a flashback.
Det. Frank Nightingale
Det. Emma Lloyd
Det. Dennis Mitchell
Det. Natalie Carmen
Joseph Morris-He blames Sidney for his sister Olivia's death if she hadn't return Jill wouldn't had killed anyone and his sister would be alive. He hates Kirby because he thinks she didn't mourn his sister,she went on with her life like Olivia didn't matter.
Mr. Leeds-A teacher at Woodsboro High,he is blackmailed by Joesph Morris into helping him after he learns Mr Leeds killed someone a couple of years earlier.
Shirley-She is stabbed in the eye and then she has her eye taken out. (Joesph)
Richie-He has his rammed into a wall then he is thrown onto a glass table he is then stabbed in the chest. (Joesph)
Carrie Stout-She has her throat slashed. (Mr Leeds)
Mariah-She is chased up to the roof of her house and then she is thrown off. (Mr Leeds)
Louis-He is stabbed in the chest then he is gutted. (Joesph)
Harold-He is is tied up to a Goalpost on the Highschool football field,stabbed repeatly and then hung. (Joesph and Mr Leeds)
Tess Martin-She is stabbed in the back of the head (Joesph)
Officer Pecard-He is shot by a unmasked Joesph
Beverly Reed-She is raped and then stabbed in the heart by a unmasked Mr Leeds.
Mr Leeds-He is shot by Mitchell because it was his sister who Mr Leeds killed a couple of years earlier.
Mitchell-He is stabbed in the back by Joesph right after he killed Mr Leeds.
Joseph Morris- He is trying to drown Kirby in the dunking tank when he is shot by both Dennis and Frank.
A couole of days later Kirby goes to visit Olivia at her grave, she says she is sorry for not mourning her after she was killed by Charlie she admitted she should have taken some time to grieve her loss since they had been friends since kindengarten.Kirby then took out a picture from her wallet it was of her,Olivia and Jill taken a couple of months before Jill went on her murder spree,she tore Jill out of the picture and then stuck the picture next to the headstone. She put the torn part of the picture with Jill back in her wallet she then left. Brianna started dating Roy. Cami watches the stars as she thinks of who her real parents are.