Scream: TNG 5 takes place after Scream: TNG 4,Jessica must battle another Ghostface who goes after her and her friends. Kirby continues her plan to make it look like Fifi killed Judy and is planning to kill more people.Jessica meets Fifi's psychotic alter ego Mimi.
Amber Heard as Jessica Mitchell
Emma Bell as Fifi/Mimi Mone
Hayden Panetierre as Kirby Reed
Matthew Lillard as Det Sam Macher
Florencia Lozano as Det Carmen Ramierez
Roger Haworth as Captain Victor Lawson
Monica Keena as Renee Prescott
Paul Wesley as Dan Wallace
Daveigh Chase-Sandy Dunham
Brittany Snow-Buffy Simmons
Julian Morris-Steve Ellison
Det Sam Macher
Det Carmen Ramierez
Captain Victor Lawson
Renee Prescott-Sidney's cousin, Kirby told her that Fifi/Mimi tried to kill Sidney and wanted to kill her too.
Steve Ellison-Renee killed him because Fifi had a crush on him and he didn't feel the same way about her,so she made it look like Fifi killed him because of that fact.
Buffy Simmons-She was Jessica's friend Renee killed her to make it look like Fifi had snapped and killed her for no reason.
Sandy Dunham-Fifi had a argument with her about a half hour before Renee killed her.
Dan Wallace-Renee killed him for the same reason she killed Buffy.
Renee Prescott-Mimi killed her when she emerged after Renee explained to Jessica and Fifi, why she was framing Fifi she wanted to protect her cousin Sidney from a monster like Fifi.
Jessica was horrified to see the look on Fifi's look after she killed Renee,she had a sick and evil smile on her face but then it soften and she said don't worry, I'm not going to hurt you Fifi likes you.She said I'm Mimi as you may have guessed she said, Mimi then said how she came to be after Sidney's other cousin the evil Jill Roberts killed her family.