Scream 15 takes place after Scream: The Murphy Law. Kirby Reed returns to Woodsboro.
- Neve Campbell As Sidney Prescott
- Georgie Henley as Hayley McDonald
- Hayden Panetierre As Kirby Reed
- Matthew Lillard As Det Sam Macher
- Brooke Vincent As Sabrina Wallace
- Josh Pais As Det Tom Wallace
- Matthew Knight as Ethan Carsia
- Ellen Wroe as Brianna Albertson
- Brianna Evigan as Lisa Lewis
- Frankie Muniz as Kurt Russo
- Rebecca Gayheart as Lois
- Portia De Rossi as Murphy
- Lee Thompson Young as Alex Jones
- Amanda Bynes as Penny Cook
- Wesley Jonathan-Michael Freeman
- Sidney Prescott
- Kirby Reed
- Hayley McDonald
- Det. Sam Macher
- Sabrina Wallace
- Det. Tom Wallace
- Ethan Carsia
- Brianna Albertson
- Lisa Lewis-She is tired of hearing about Billy Loomis and Jill Roberts she wants to be considered to be the greatest Ghostface serial killer.She is very determinded to kill Sidney Prescott
- Lois-Kirby Reed is her college roommate at Woodsboro University and because she is so famous in her school due to fighting the events of Scream series she get jealous and want to kill her
- Michael Freeman-Lisa killed him because she wanted to prove a girl could kill a strong athlete by herself.
- Penny Cook-Like Jill, Lisa didn't want friends she killed her best friend Penny because she felt like it
- Alex Jones-Lisa chased Alex through the Woodsboro High hallways to the gym she killed him when she stabbed him through the neck she then dragged his body to the lockroom and left him there.
- Kurt Russo-She killed him in his kitchen she stabbed him in the chest she then gutted him and then she poked her knife through his eyes.
- Lisa Lewis-She attacked Kirby Reed and Sidney then Hayley threw her through a window in her house she then Sidney shot her 2 times in the head with a gun she had hidden in the kitchen to make sure she didn't come back for a final scare.
- Lois-Hayley helped Kirby on her feet and she grabbed a shotgun, then shot Lois in the heart with a bullet and then Sidney stabbed her in the head 9 time which finally kills her.
Sidney was postive it was now over she had spent most of her adult life fighting these killers and now she could finally live a normal life because she found out she was going to have a baby.Kirby Reed moved back into her old house and couldn't wait to find a new boyfriend.Sam Macher promoted to LT.Fifi Mone was released from the hospital and she went to say goodbye to her friends before she left Woodsboro.