Scream 18 takes place after scream 17. Dewey and Sidney are getting married to each other but a new Ghostface killer with a mysterious connection to Jill Roberts is killing the wedding guests.
Neve Campbell as Sidney Prescott
Julia Roberts as Emma Robinson
David Arquette as Sheriff Dewey Riley
Matthew Lillard as Det Sam Macher
Brooke Theiss as Debbie Macher
Matthew Knight as Ethan Carsia
Ellen Wroe as Brianna Albertson
Scott Caan as Peter Long
Cole Hauser as Rodney Everette
Shauna McDonald as Julie McGuire
Chris Klein as Bobby Lombardi
Julia Stiles as Ellen Wright
Eric Cristian Olson as Vince Dolan
Michelle Trachtenberg as Naomi Lively
Sheriff Dewey Riley
Det Sam Macher
Bobby Lombardi-He was a serial killer Jill had commuinated on the computer with before she started her killing spree with Charlie Walker.
Brianna Albertson-At the same time Jill was on her killing spree, Brianna was killing athletes and cheerleaders.
Vince Dolan-He is attacked while on his hotel balcony and then pushed over the railing.(Bobby)
Ellen Wright-She is a cheerleader coach she is attacked in her office,she has her head slammed on the desk then she has a knife thrust through the back of her head.(Brianna)
Peter Long-He is a friend of Dewey he has his head bashed in with a lead pipe then the killer stabs his eyes with his knife.(Bobby)
Naomi Lively-She is a former basketball player she is stabbed on both arms and then she is stabbed in her heart (Brianna)
Rodney Everette-He is Dewey's best friend and also his best man, he is attacked at the church after the wedding rehersal, he is gutted and left on the church floor(Bobby)
Emma Robinson-She is Sidney and Jill's aunt she has her throat slit by an unmasked Brianna in front of a shocked Sidney.
Bobby Lombardi-He is shot by Sam and Debbie Macher when he tries to attack Dewey.
Brianna Albertson-She is killed by Sidney who stabs her with a broken piece of glass from a wine bottle deeply in her heart after she charged at Sidney.
Sidney and Dewey decide not to get married because he is not completely over Gale. Ethan is upset that Brianna was Ghostface and is now dead. She was his only friend at high school and he'll miss her.