Scream 23 takes place after Scream 22. Fifi is dead, Sidney is still alive and also Hayley's evil twin sister Lauren is still alive. Sidney, Jessica, Ethan and Hayley find out is another Ghostface is after Thomas. Can Thomas, Sidney, Hayley, Jessica and Ethan stop Lauren as Ghostface this time with a another Ghostface killer.
- Keanu Reeves as Thomas Connor
- Neve Campbell as Sidney Prescott
- Georgie Henley as Hayley McDonald/Lauren Malloy
- Matthew Knight as Ethan Carsia
- Chelsea Tavares as Kelli Sanchez
- Amber Heard as Jessica Mitchell
- Justin Whalin as Steve Cole
- Justina Machado as Emma Kalarjian
- Jim Belushi as Eston Whitaker
- Zoe Saldana as Yacima Cheeks
- Lena Clark as Kristy
- Joel McHale as Richard Burns
- Sharon Stone as Mindy Pearson
- Nan Zhang as Nancy Yi
Lauren Malloy-She is Michael Myers as Jill Roberts would say.
Richard Burns- He is a AA counselor who hates Thomas because one night when Thomas was driving drunk a year ago he accidently hit Richard's wife when she was trying to cross the road,the accidently left her in a wheelchair.
Nancy Yi-She is attacked and has the letter X slashed on her chest with a kinife when she is killed. (Lauren)
Kristy-She is getting ready to drive home after she had a few drinks when the killer comes running up and brutally stabs her 5 times in the back with his knife.(Richard)
Mindy Pearson-She is killed because her initials are MP like Maureen Prescott. It wil be revealed in the next movie that it was Jill Roberts who killed her.
Steve Cole-He is killed when he is getting ready to go out on a date she has his head smased into a mirror then his throat is glassed with a piece of glass. (Lauren)
Emma Kalarjian-She is killed after she leaves a AA meeting she is hit a car then the driver get out of the car kneels down in sticks a knife deeply in her forehead .(Richard)
Eston Whitaker-He is killed and gutted because he is a bartender and he was the one who served Thomas the drinks the night he hit Richard's wife.(Richard)
Yacima Cheeks-She is killed because the killer wasn't happy with her answers to the trivia quiz. (Lauren)
Richard Burns-He is killed by Thomas when he tries to shove a drink down his throat but instead Thomas forces him to drink it then he chokes on the drink when Thomas grabs him by the thoart and squeezes hard.
Lauren Malloy-She tries to run down Hayley with a car but instead hits a pole and it explodes a few minutes later, Lauren was able to get out of the car through the passenger side but the door was lock. Lauren try open the 2 door but is was lock. The car blew up and Lauren is on fire and Lauren scream and hold the gun then Lauren die.