Scream 25 takes place after the events of Scream 24. Lauren Malloy is not dead, She is still alive. After she wake in her coma and kill 5 doctors. Thomas, Sidney, Hayley, Kelli, Jessica and Ethan found Lauren is still alive. Sidney wanted know who made Lauren is still alive and Hayley found out is another Ghostface is after Thomas again but is new Ghostface. Jill Roberts is also still alive and she wants to prove she is the most feared Ghosface ever.
- Keanu Reeves as Thomas Connor
- Georgie Henley as Hayley McDonald/Lauren Malloy
- Neve Campbell as Sidney Prescott
- Emma Roberts as Jill Roberts
- Chelsea Tavares as Kelli Sanchez
- Amber Heard as Jessica Mitchell
- Michael Madsen as Det Dennis Mitchell
- Kristin Stewart as Belle Pallack
- Channing Tatum as Charlie Tate
- Chloe Moretz as Lydia King
- Daniel Radcliff as William Prince
- Matthew Knight as Ethan Carsia
- Ariana Grande as Niley Krinkey
- Alyson Hannigan as Billie Russell
- Johnny Galecki as Alvin Hill
- Jamie King as Hillary Stone
Emma Roberts and Daniel Radcliff were in Final Destination 8 and Final Destination 10. Also Emma Watson and Daniel Radcliff were in the Harry Potter series.
Emma Bell as Fifi Mone-She up in a news clip that a mysterious blonde is watching.
Ashely Roberts as Sally/Samantha Mone-Sally shows up in a flashback scene. Samantha is seen arguing with Mike about Fifi in a flashback scene.
David Henrie as Jimmy Mone-He shows up in a flashback scene.
Kyle Lower as Mike Mone-He is in a flashback scene.
Emma Watson as Crystal Mone-She is shown being killed by Jill in a flashback scene.
Anton Yelchin as Drake Mone-He also shows up in a flashback scene
Sharon Stone as Lizzy Mone-She is shown being killed by Sally in a flashback scene.
Jeff Bridges as Grandpa Luke Mone-He is shown in a flashback scene visiting Fifi.
Susan Sarandon as Grandma Phoebe Mone-She is shown in a flashback scene visiting Fifi.
Nicholas Cage as Robert Mone-He is shown in a flashback scene getting killed by Jill.
Emily Blunt as Emily Mone-She is also shown in a flashback getting killed by Jill.
Jimmy Bennett as Tommy Mone-He is shown in a flashback scene.
Lauren Malloy- She recovered from her injuries from when she jumped from the car before it exploded and she's back for more killing.
Jill Roberts-She isn't happy that someone is stealing the spotlight and that means people will die painfully.She also has a friend with her.
William Prince-He is Hayley's ex-boyfriend who hate Thomas, wanted him dead and he is also Jill's accomplice.
Ethan Carsia-He is bashed in the head with a hammer. (Lauren)
Billie Russell-She is stabbed in the stomach then her chest is cut open and she is gutted,she also has her heart take out with a knife. (Jill)
Charlie Tate-He is attacked and thrown of a apartment building roof onto a police car.(William)
Lydia King-She is tied to a chair and then spun around as she is spinning she is repeatly stabbed. (Jill and William)
Hillary Stone-She is stabbed in her heart. (Lauren)
Alvin Hill-He is attacked while he is on his cell phone at Hayley's party the killer runs up and stabs him on the forehead.(Jill) Her accomplice unmasks and it's revealed to be Hayley's ex-boyfriend William.
Belle Pallack- She is stabbed with a screw driver by a unmasked Lauren pretending to be Hayley.
William Prince-He is killed by an unmasked Lauren at the party in front of the guests except everyone thinks she's Hayley at the time.Hayley walks in with Sidney when she hears all the screaming
Lauren Malloy-She is stabbed in the back with a knife by Ghostface who then takes a gun out of a pocket in the costume and shoots Sidney in the shoulder then unmasks everyone except Sidney is shocked to see the evil and psychotic Jill is still alive.
Jill Roberts-She grabs Sidney and forces her to come with her when Jessica's uncle Dennis arrives. Outside when they get to a bridge near Hayley's house, Jill tries to push Sidney over the railing but SIdney won't go over they fight and Sidney is able to overpower her insane cousin despite her hurt shoulder,Jill escapes from her grasp and jumps over the railing to her death when the police arrive at the bridge.
Hayley is heartbroken that Ethan is dead and she'll miss him. Annie is the only Carsia family of the world.The mysterious long haired blonde that was watching the news clip turned out to be the very much alive Kirby Reed!