Scream 26 takes place after the events of Scream 25. Jill is thought to be dead and Hayley's evil twin sister Lauren survived the stabbing in the back and she escaped from the hospital once again this time she kills 1 doctor and 4 cops. Kirby returns to Woodsboro and finds out her sister was killed by Fifi in a fight. Lauren continues with her plan to kill Hayley and everyone. Can Thomas, Hayley, Sidney, Kirby, Jessica, and Kelli stop Lauren as Ghostface?
- Keanu Reeves as Thomas Connor
- Georgie Henley as Hayley McDonald/Lauren Malloy
- Neve Campbell as Sidney Prescott
- Hayden Panettiere as Kirby Reed
- Amber Heard as Jessica Mitchell
- Michael Madsen as Det Dennis Mitchell
- Chelsea Tavares as Kelli Sanchez
- Jimmy Smits as Mr Hector Sanchez
- Molly Burnett as Caroline Mitchell/She is Dennis's daughter
- Christian Bale as Kirk Mason
- Jessica Biel as Helen Slaten
- James Masters as Randall Malone
- Selma Hayek as Mitzi Sanchez
Lauren Malloy-She still wants to kill Hayley's friends.
Mitzi Sanchez-She is tied up Lauren then stabs her and opens up her chest and takes out her intenstines to show it to Hector who is also tied up.
Hector Sanchez-He is forced to drink cleaning solution by Lauren she then slashes his throat when he throws it up.
Randall Malone-He has his arm torn off by a sword by Lauren then she takes the sword and stabs it deep in his heart.
Kelly Sanchez-She is crushed between 2 cars when an unmasked Lauren hits her with a car she had stolen she then speeds away.
Helen Slaten-She is butchered by Lauren who tried to stop her from stabbing Hayley after she had stabbed Sidney.
Lauren Malloy-She is about to stab Hayley to death when she is shot by Sidney who survived the stabbing.
Sidney is recovering in the hospital when she gets a call saying she should enjoy her time she has left because she will die soon.