Scream 36: There will bloodshed takes place after the events of Scream 35: Scream For Me. Jill Roberts survived being shot in the leg and stabbed in the heart by Sidney. Another Ghostface has arrived and wants to kill Kirby Reed. Cami Watson learns that she is connected to the Mones.
- Neve Campbell as Sidney Prescott
- Georgie Henley as Hayley McDonald/Lauren Malloy
- Josh Brolin as Robert Morgan
- Hayden Panetierre as Kirby Reed
- Emma Bell as Cami Watson
- Michael Madsen as Detective Dennis Mitchell
- Amber Heard as Jessica Mitchell
- Molly Burnette as Caroline Mitchell
- Billy Burke as Bobby Reno/Kirby's uncle
- Lisa Wilcox as Det Natalie Carmen
- George Eads as Nick Watson/Cami's older brother
- Charlie Sheen as Carlos Martinez
- Shelly Hennig as Tatum Raines
- Joshua Jackson as Peter Newman
- Marguerite Moreau as Colleen Allen
- Thomas Dekker as Greg Ellis
- Christian Serratos as Kristine Ruiz
Tatum Raines-She is an actress and Charlie Walker's ex girlfriend,she blames Kirby for Jill talking him into helping her kill all those innocent people and she says she always knew Jill was a psycho but everyone in the group was blind to it.
Peter Newman-He is a aspiring movie director who wants to make these murders into a movie.
Carlos Martinez-He is bashed on the head with a sledge hammer then he is stabbed repeatly. (Tatum and Peter)
Natalie Carmen-She is stabbed in her back 2 times then she is stabbed in the back of head as she tries to crawl away. (Tatum)
Nick Watson-He is stabbed in the neck then as his tongue out,He was killed so he wouldn't tell Cami her connection to the Mone family, (Mimi that will be revealed in the next movie )
Kristine-She has her head shoved onto a stove then she has head put in the oven after and it's turned on to 400 degree's and she's cooked to death.(Tatum)
Greg Ellis- He is tied up to a chair and pushed through a window he falls 10 stories to his death.(Peter)
Colleen-She is attacked, raped then she has her throat slit. (Peter)
Bobby Reno- He is shot to death by an unmasked Tatum in front of Kirby and Jessica.
Peter-he is killed by Jessica when she stabs in the heart when he tries to attack her while Kirby and Tatum are fighting.
Tatum-After she is arrested and is being taken to the police car she is shot, the police go after the killer and Dennis catches up when he hears a female scream and a gunshot.He sees a woman screaming saying she did it!He turns to look and he sees Hayley McDonald standing over a dead police officer with a gun in her hand. As she is being taken away her deranged twin Lauren Malloy is seen lurking around the corner with a evil grin on her face.
Hayley tries to explain to Dennis that it was her twin Lauren who killed that girl Tatum Raines,he says he wants to believe her but they found GSR on her hand she said yes she fired the shot but that happened because Lauren grabbed her hand and forced her to fire the gun when they were fighting she then hit her and ran away. She said the lady they saw came out of her house right before they showed up but she didn't see what happened.Sidney then came into the police station saying she had a lead on where her evil little cousin Jill could be,Dennis told her to tell him where she could be at and he would go find her bring her back to Woodsboro.Dennis then called his old friend Det Frank Nightingale and asked him to fill in for a while because he had to leave town to help find a serial killer.