Street Fighter: The Rise of Akuma is the sequel to Street Fighter: The Legend of Chun-Li.
- Kristen Kreuk as Chun-Li: After avenging her father by killing M. Bison she is contacted by Gen to enter a tournament Street Fighter Tournament. She initially refuses, but decides to enter when she hears that a man named Sagat has taken over Bison's organization of Shadaloo. She wants to end the organization once and for all.
- Robin Shou as Gen: Chun-Li's mentor who shows her the ad for the Street Fighter Tournament. He enters as well.
- James Kyson Lee as Ryu: A warrior who was trained by Gouken, the former leader of the Order of the Web.
- Justin Hartley as Ken Masters: Ryu's best friend.
- Jet Li as Akuma: A mysterioius warrior that eneters the Street Fighter Tournament.
- Chris Klein as Charlie Nash: The interpol agent who helped Chun-Li defeat M. Bison.
- Chow Yun-Fat as Gouken: Ryu and Ken's deceased mentor.
- Dalip Singh as Sagat: A Thai crime lord who now runs Shadaloo.
- Taboo as Vega: After being defeated by Chun-Li, Vega seeks vengeance for his humiliation.
- Tyler Mane as Blanka: A monstrous fighter who partakes in the Street Fighter tournament.
- Kevin Nash as Zangief: A Russian wrestler who is a part of the Street Fighter Tournament.
- Arnold Vosloo as Dhalsim: A pacifist who only fights so he can earn money to provide for his village.
- Sarah Michelle Gellar as Cammy
- Doug E. Doug as Dee Jay