The Bureau is the title to an upcoming film, which is planned to be part of a series.
- Christian Bale as Ian McCain: An FBI agent, and one of the best.
- Johnny Depp as Ryan Knight: An thug for hire working for Samuel Marx that is captured by Ian and offers his services in bringing down the drug lord Samuel Marx, in exchange for amnesty.
- Shia LaBeouf as Kyle Kline: A new recruit in the FBI who is assigned to work with Ian McCain. Ryan Knight gives him the nickname KK which Kyle at first fights against but then later accepts.
- Summer Glau as Victoria Winters: A new recruit in the FBI who went through training with Kyle Kline.
- Harrison Ford as Charles Walker: The head of the department of the bureau that Ian McCain is in.
- Bruce Willis as Robert MacReady: A senior FBI Agent, and old friend of Charles Walker. He was a mentor to Ian McCain, Michael Stamos, and Franklin Duncan.
- Adam Baldwin as Franklin Duncan: A hot headed and shady FBI agent.
- John Malkovitch as Samuel Marx: A drug lord in New York City. He killed Ian McCain's first partner Michael Stamos.
- Steve Buscemi as Vincent Bateman: A schizophrenic criminal that works for Samuel Marx. He worked and was friends with Ryan Knight, but left him behind during a shootout with the FBI so he could take over Ryan's gang.
- Jason Statham as Michael Stamos: Ian McCain's partner that is killed by Samuel Marx when he tried to have Charles Walker killed. He and Ian were best friends.
- Eric Roberts as Gregory Mason: One of Samuel Marx's lieutenants.
- Tobey Maguire as Richard Andrews: An investigative journalist that discovers a connection between Samuel Marx and industrialist Wyatt Dohring, and is then hunted down by Marx's men because he took a picture of the two together.
- Mary Elizabeth Winstead as Sarah Fey: A fellow worker of Richard Andrews, and she harbors a crush on him.
- Christopher Lee as Wyatt Dohring: An industrialist that is in an alliance with drug lord Samuel Marx. His company is called Dohring Industries.
- Malcolm McDowell as Frederick McCain: Ian's father, and former FBI agent. He is now retired.
- Christopher Walken as Quentin Baines: One of Samuel Marx's lieutenants.