The Return of Lauren Malloy, Mimi Mone, Jill Roberts and Roman Bridger takes place after Scream: The Murder Mystery. Someone who been a ghostface has resurrected the 4 most vicious killers. Lauren Malloy, Mimi Mone, Jill Roberts and Roman Bridger. Can Thomas, Hayley, Sidney, Cami, Hannah, Jessica, Ethan, Brianna, Missy, Hayley Mitchell and Joanne Watson stop them?
- Keanu Reeves as Thomas Connor
- Georgie Henley as Hayley McDonald/Lauren Malloy
- Neve Campbell as Sidney Prescott
- Emma Bell as Cami Watson/Mimi Mone
- Emma Roberts as Jill Roberts
- Scott Foley as Roman Bridger
- Daveigh Chase as Hannah Roberts
- Amber Heard as Jessica Mitchell
- Matthew Knight as Ethan Carsia
- Ellen Wroe as Brianna Albertson
- Dakota Fanning as Missy Gibson
- Caitlin Carmichael as Hayley Mitchell
- Rowan Blanchard as Joanne Watson
- Thomas Connor
- Hayley McDonald/Lauren Malloy "Lauren was one of four killers was alive in this movie"
- Sidney Prescott
- Cami Watson
- Hannah Roberts
- Jessica Mitchell
- Ethan Carsia
- Brianna Albertson
- Missy Gibson
- Hayley Mitchell
- Joanne Watson
Jill Roberts- She's still obsessed with killing Sidney and everyone esle who gets in her way including her cousin Roman Bridger, and she wants to avenge her twin sister's murder so Lauren is also a target.No one in Woodsboro is safe with Jill around.
Roman Bridger-Roman wants to kill both Sidney and Jill.
Lauren Malloy-Lauren Malloy is after her sister Hayley
Mimi Mone-She is now just killing for the thrill.