The Secrets of Lauren Malloy or Scream 38: The Secrets of Lauren Malloy takes place after events of Scream: Resurrection. Detective Frank Nightingale and Detective Emma Lloyd find out Hayley has a twin sister Lauren Malloy, Hayley insists to Frank that her sister is still alive and framed her for that police officer's murder.
- Gary Sinise as Detective Frank Nightingale
- Alicia Silverstone as Detective Emma Lloyd
- Georgie Henley as Hayley McDonald/Lauren Malloy
- Emma Bell as Cami Watson
- Hayden Panettiere as Kirby Reed
- Amber Heard as Jessica Mitchell
- Logan Browning as Kimberly Jansen
- Christina Millian as Kara Franks
- Jennifer Sky as Melissa Browning
- Michael Cera as James Quinton
- Lucas Grabeel as Kevin Collins
- Anson Mount as Officer Greg Brooks
- Whitney Able as Carrie Smith
Hayley McDonald/Lauren Malloy "Lauren does not die, she's in a coma"
Lauren Malloy - She tries to make it look like Hayley has gone psycho after she is released on bail.
This is the first time Ghostface is unmasked the whole movie.
Officer Greg Brooks -Lauren sabatoges his car she then come up from behind him when he is looking at it and slits his throat.
Carrie Smith - Lauren strangles her and then puts her in a locker at her work.Her body is later found by Emma and Hayley.
James Quinton -He is having dinner at his house with who he thinks is Hayley at his house when suddenly Lauren shoves a steak kabob down his throat.
Kevin Collins - Lauren knocks him out with a lead pipe then she ties him up and she then guts him.
Kara Franks -Lauren runs at her and stabs her in the stomach with her knife as she is walking to the elevator at her work, she then opens an elevator door and pushes her down the shaft, Kara 's body breaks through the glass top of an elevator that is coming up.
Melissa Browning - She is killed when Kara's body fell on her after falling through the glass top of the elevator.
Kimberly Jansen -She is burned to death when Lauren throws gasoline on her and then lights a match and throws it at her.
James Quinton death was a homage to the movie Happy Birthday To Me.
Lauren Malloy tries to escape from Frank Nightingale and Emma Lloyd whe suddenly she is hit by a car she flies up on to the trunk of the car the rolls off, the driver of the car turned out to be Hayley who had to stop her sister. Hayley is cleared of all the murders and at the hospital. Hayley and Frank Nightingale learn from the doctor Lauren is alive but in a coma.